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SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.8
Supplement Facts
Serving Size: 1 Caplet
Amount Per Serving
%DV
Zinc (as Zinc Gluconate)
50 mg
455%
Top Medical Research Studies
9
Zinc supplementation benefits MS models
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
Study highlights zinc's impact
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.
Directly addresses autoimmune relationships
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
8
Zinc transport's role in T cells
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.
High relevance to autoimmune disease
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Read More
Most Useful Reviews
8.8
Improved skin condition
Great product! My skin improved significantly. The zinc dosage is just right, causing no nausea. Although the capsule shell is noticeable, it is easy to swallow. I've noticed a marked improvement in my skin, especially with acne, which has reduced considerably. I'm hopeful for further benefits regarding my autoimmune disorder. I will order more and highly recommend it!
Read More
9.5
Effective cold recovery
My most beloved zinc! I’ve ordered it for many years, and I definitely feel its effect, particularly when I have a cold. Recovery is faster and I feel better almost instantly.
Read More
9.5
Essential mineral benefits
Excellent! Where would we be without zinc? It’s crucial for the body’s functions, aiding the immune, nervous, and endocrine systems, and it combats autoimmune disorder symptoms like acne and fatigue. To optimise absorption, I recommend avoiding coffee and dairy for an hour and a half before taking zinc.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
9
Zinc supplementation benefits MS models
Dietary zinc status is associated with ZnT3 (SLC30A3), IL-6 gene expressions and spinal cord tissue damage in spinal cord tissue in a cuprizone-induced rat Multiple Sclerosis model.
Study highlights zinc's impact
We explored how dietary zinc levels influence spinal cord damage and gene expressions associated with Multiple Sclerosis (MS) using a cuprizone-induced rat model. The study included 46 adult male Wistar rats divided into five groups, with some receiving zinc supplementation while others followed a zinc-deficient diet.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
After eight weeks of treatment, we found that the rats with MS symptoms showed elevated markers of tissue damage and inflammation, particularly in the groups that lacked zinc. Notably, those receiving zinc supplementation exhibited significantly reduced levels of harmful substances, bringing them back closer to control levels.
Our findings highlight zinc's protective effects in a model of MS, suggesting that incorporating zinc into treatment plans could help alleviate some symptoms associated with this autoimmune disorder. This is promising for future treatment strategies for those affected by MS.
Read More
9
Zinc intake benefits RA bone health
The association between dietary zinc intake and osteopenia, osteoporosis in patients with rheumatoid arthritis.
Directly addresses autoimmune relationships
We aimed to understand how dietary zinc intake influences the risk of developing osteopenia and osteoporosis in patients with rheumatoid arthritis (RA). Our study relied on data collected from the National Health and Nutrition Examination Survey, spanning several years. Through careful analysis using univariate and multivariate logistic regression models, we were able to uncover significant associations between dietary zinc levels and bone health in this population.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
What we found was encouraging: higher zinc intake appeared to lower the chances of these serious bone conditions among RA patients. Our research also went further by examining various factors such as age, body mass index (BMI), and pre-existing health issues like diabetes and hypertension. This comprehensive approach led us to conclude that adequate dietary zinc is crucial for maintaining bone health in individuals with RA, though we noted the need for more extensive long-term studies to corroborate these findings and delve deeper into the underlying mechanisms at play.
Read More
8
Zinc transport's role in T cells
SLC39A10 is a key zinc transporter in T cells and its loss mitigates autoimmune disease.
High relevance to autoimmune disease
We identified an important link between zinc transport and autoimmune disorders, specifically focusing on the protein SLC39A10 and its role in T cells. Through our study, we discovered that two specific genetic variations in the SLC39A10 gene are associated with inflammatory bowel disease (IBD). To further explore this connection, we created genetically modified mice with a targeted deletion of the Slc39a10 gene in T cells.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Our findings revealed that the loss of SLC39A10 significantly protects against the progression of both IBD and experimental autoimmune encephalomyelitis (EAE). Notably, we also observed that the absence of this transporter led to increased cell death, independent of common pathways usually associated with apoptosis. This indicates that SLC39A10 plays a crucial role in maintaining the health of T cells by facilitating zinc import, which is essential for DNA replication when T cells are activated.
Our research contributes to a deeper understanding of how zinc homeostasis impacts immune function. The insights gained from this study suggest that targeting zinc transport could present new therapeutic options for managing T cell-related autoimmune diseases.
Read More
8
Zinc's role in alopecia areata
Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis.
High relevance to zinc effects
We analyzed how zinc levels in the body relate to alopecia areata (AA), an autoimmune disorder that affects hair loss. Our research involved a systematic review of 34 studies, gathering data from nearly 5,000 participants across 16 countries. By examining various studies, we sought to understand if zinc supplementation could be beneficial for those suffering from AA.
The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.
Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
The results were striking. We found that individuals with alopecia areata had significantly lower levels of zinc and vitamin D compared to healthy individuals. Specifically, the data indicated that those with vitamin D deficiency faced a heightened risk of developing AA. This suggests that replenishing these nutrients might help manage the disease.
Importantly, we didn't find a significant difference in copper levels between AA patients and healthy controls, indicating that not all trace elements play the same role in this condition. Overall, our findings highlight the potential of zinc and vitamin D as targeted treatments for alopecia areata, offering new hope for those affected by this condition.
Read More
7
Zinc supplementation eases neutrophil activity
Zinc Supplementation Reduces the Formation of Neutrophil Extracellular Traps by Decreasing the Expression of Peptidyl Arginine Deiminase 4.
High relevance to autoimmune disorders.
We aimed to explore how zinc supplementation might influence immune responses, particularly focusing on neutrophil activity in the context of autoimmune diseases. To do this, we simulated inflammatory conditions typically seen in such disorders using specific cytokines, interleukin-17 (IL-17) and tumor necrosis factor (TNF)-α.
Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.
Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
Our findings indicated that elevating zinc levels significantly reduced the formation of neutrophil extracellular traps (NETs), which are often implicated in tissue damage during autoimmune flare-ups. We also discovered that zinc supplementation lowered the expression of a protein called peptidyl arginine deiminase 4 (PAD4), which is associated with NET formation.
Interestingly, zinc not only decreased harmful neutrophil activity but also boosted the production of beneficial proteins like interleukin-1 receptor antagonist (IL-1RA) and IL-8 in the activated cells. Overall, maintaining adequate zinc levels seems crucial for preserving healthy immune function and preventing the harmful overactivity of neutrophils, suggesting its potential as an adjunct treatment in managing autoimmune conditions.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 7 Reviews
7.8
9.5
Effective cold recovery
My most beloved zinc! I’ve ordered it for many years, and I definitely feel its effect, particularly when I have a cold. Recovery is faster and I feel better almost instantly.
9.5
Essential mineral benefits
Excellent! Where would we be without zinc? It’s crucial for the body’s functions, aiding the immune, nervous, and endocrine systems, and it combats autoimmune disorder symptoms like acne and fatigue. To optimise absorption, I recommend avoiding coffee and dairy for an hour and a half before taking zinc.
Read More
8.8
Improved skin condition
Great product! My skin improved significantly. The zinc dosage is just right, causing no nausea. Although the capsule shell is noticeable, it is easy to swallow. I've noticed a marked improvement in my skin, especially with acne, which has reduced considerably. I'm hopeful for further benefits regarding my autoimmune disorder. I will order more and highly recommend it!
Read More
8.8
Quick COVID recovery
I ordered this during my COVID illness. My husband and I take one tablet daily, which aids in a swift recovery. The tablets are quite large and have a peculiar taste, so drinking plenty of water is necessary.
7.5
Cold symptoms relief
This product works well during cold or viral periods when combined with vitamin C. It helps facilitate a quicker recovery. However, I had issues with the last two cans turning to powder in my mouth, causing nausea. I found that drinking lots of water, and sometimes a lemon slice, helped alleviate that. I didn't experience this with my first purchases.
Read More
